Category Archives: Uncategorized

Podcast: a Career in Academia and Founding a BioTech Company

The Offspring group of the Max Planck PhD net talks with Tony about his carreer in academia and how he founded two BioTech companies. The offspring magazine podcast series is “hosted for doctoral researchers by doctoral researchers. The team wants to make the process of getting a doctorate more transparent and raise awareness for career […]

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Opening: PhD student (m/f/d) in Biophysics

The Hyman and Zechner labs are looking for a PhD student to research the control of cellular noise via phase separation. Brief summary: Liquid condensates provide a potential mechanism to control molecular fluctuations in cells. We have recently provided a first proof of principle of this idea using theory and single-cell experiments. In this project, […]

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Die neue Biologie der Tröpfchen

Berlin newspaper Tagesspiegel article of Sascha Karberg about the discovery and applications of phase separation “Es ist eine Entdeckung, die das Verständnis der Zelle revolutioniert. Die erste Firma, die das neue Wissen für neue Therapien nutzt, kommt nun nach Berlin”. click here for full article in german

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Our kinetochore paper is selected for the 65th birthday collection of JCB

For the collection celebrating the 65th anniversary of the Journal of Cell biology, our paper Functional Analysis of Kinetochore Assembly in Caenorhabditis elegans was selected for its contribution to “dissecting the mechanics of cell division”. The paper from 2001 by Karen and Arshad, postdocs in our lab at the time has great company there. Click […]

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Enrichment of soluble tubulin at centrosomes

Recent work from Dresden (2017) suggests that centrosomes are condensates that nucleate in part by concentrating soluble tubulin. Here we show that indeed tubulin is extremely concentrated at centrosome in C. elegans embryos, suggesting that such a tubulin concentration could indeed play a key role in nucleation. References 1- 2-

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Small molecules that dissolve stress granules

In ALS, a mutated nuclear protein, FUS (fused in sarcoma), mislocalises to the cytoplasm and aggregates in stress granules. This leads to a liquid to solid transition of the granules and a consequent degeneration of the motor neuron (motor neuron die-back ). We show that lipoamide and lipoic acid can prevent the aggregation of FUS and consequently […]

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Suzanne Eaton

We, past and current members of the Hyman lab, are reeling from the sudden and tragic loss of Suzanne Eaton. She was a wonderful person who lives on in our hearts. In this difficult time, we stand together with her family and colleagues.

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FlexiBAC, our open source protein expression system

One of great things here at the MPI-CBG are our Service and Facilities, among them the protein expression facility (PEPC), which has been heavily used by us in recent years. In collaboration with Jeff Woodruff, a former postdoc, they developed FlexiBAC, an amazingly versatile protein expression system in insect cells, which was developed with a […]

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We held the first EMBO phase separation course here at the MPI-CBG

From 4th to 13th February we taught our first EMBO course Methods for Studying Phase Separation in Biology here in Dresden at the MPI-CBG and CSBD. The course was organized together with the Tang and Alberti lab, including morning lectures, theoretical or experimental parts during the day and a relaxing evening part. Importantly, we included […]

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Phase separation buffers noise in cells

Now, the paper got published in Science! Congratulations to Adam and all the coauthors. And check out the perspective article about the paper from the Brangwynne lab (@Brangwynnelab), as well as the press article from the CSBD and from the CBG . We are excited to share our pre-print which explores how phase separation affects […]

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