Publications

Recent Publications

Recent Publications

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Molecular mechanisms of stress-induced reactivation in mumps virus condensates.

Zhang X, Sridharan S, Zagoriy I, Eugster Oegema C, Ching C, Pflaesterer T, Fung HKH, Becher I, Poser I, Müller CW, Hyman AA, Savitski MM, Mahamid J.Cell. 2023 Apr 27;186(9):1877-1894.e27. doi: 10.1016/j.cell.2023.03.015.
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CD-CODE: crowdsourcing condensate database and encyclopedia.

Rostam N, Ghosh S, Chow CFW, Hadarovich A, Landerer C, Ghosh R, Moon H, Hersemann L, Mitrea DM, Klein IA, Hyman AA, Toth-Petroczy A.Nat Methods. 2023 May;20(5):673-676. doi: 10.1038/s41592-023-01831-0
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Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions. 

Kar M, Dar F, Welsh TJ, Vogel LT, Kühnemuth R, Majumdar A, Krainer G, Franzmann TM, Alberti S, Seidel CAM, Knowles TPJ, Hyman AA, Pappu RV.Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2202222119. doi: 10.1073/pnas.2202222119. Epub 2022 Jul 5.
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 SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.

Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA.Mol Cell. 2022 Oct 6;82(19):3712-3728.e10. doi: 10.1016/j.molcel.2022.08.031. Epub 2022 Sep 22
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Adaptation to environmental temperature in divergent clades of the nematode Pristionchus pacificus. 

Leaver M, Moreno E, Kayhan M, McGaughran A, Rödelsperger C, Sommer RJ, Hyman AA.Evolution. 2022 Jun 13. doi: 10.1111/evo.14520. Online ahead of print.PMID: 35696526
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Molecular mechanism of stress-induced reactivation in mumps virus condensates
Xiaojie Zhang, Sindhuja Sridharan, Ievgeniia Zagoriy, Christina Eugster Oegema, Cyan Ching, Tim Pflaesterer, Herman KH Fung, Ina Poser, Christoph W Müller, Anthony A Hyman, Mikhail M Savitski, Julia Mahamid
Biophysical Journal 121 (3), 148a (2022). doi.org/10.1016/j.bpj.2021.11.1982
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Sequence-dependent surface condensation of a pioneer transcription factor on DNA   

Jose A Morin, Sina Wittmann, Sandeep Choubey, Adam Klosin, Stefan Golfier, Anthony A Hyman, Frank Jülicher, Stephan W Grill. Nature Physics, 1-6. doi.org/10.1038/s41567-021-01462-2 (2022)
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Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils.   

Kar M, Posey AE, Dar F, Hyman AA, Pappu RV.Biochemistry. 2021 Nov 2;60(43):3213-3222. doi: 10.1021/acs.biochem.1c00501. Epub 2021 Oct 14. (2021)
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Quantitative theory for the diffusive dynamics of liquid condensates.   

Hubatsch L, Jawerth LM, Love C, Bauermann J, Tang TD, Bo S, Hyman AA, Weber CA.Elife. 2021 Oct 12;10:e68620. doi: 10.7554/eLife.68620.
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Local thermodynamics govern formation and dissolution of Caenorhabditis elegans P granule condensates.   

Fritsch AW, Diaz-Delgadillo AF, Adame-Arana O, Hoege C, Mittasch M, Kreysing M, Leaver M, Hyman AA, Jülicher F, Weber CA.Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2102772118. doi: 10.1073/pnas.2102772118
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ASCB Keith Porter Lecture.    

Hyman AA.Mol Biol Cell. 2020 Dec 15;31(26):2864-2867. doi: 10.1091/mbc.E20-08-0566.PMID: 33320708
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Protein condensates as aging Maxwell fluids.    

Jawerth L, Fischer-Friedrich E, Saha S, Wang J, Franzmann T, Zhang X, Sachweh J, Ruer M, Ijavi M, Saha S, Mahamid J, Hyman AA, Jülicher F.Science. 2020 Dec 11;370(6522):1317-1323. doi: 10.1126/science.aaw4951.PMID: 33303613
 
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Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production.           

Iserman C, Desroches Altamirano C, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D, Guenther UP, Hentze MW, Moses AM, Hyman AA, Kramer G, Kreysing M, Franzmann TM, Alberti S. Cell. 2020 Apr 29:S0092-8674(20)30404-9. doi: 10.1016/j.cell.2020.04.009. Online ahead of print. PMID: 32359423

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RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.          

Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Chang YT, Guck J, Honigmann A, Mahamid J, Hyman AA, Pappu RV, Alberti S, Franzmann TM. Cell. 2020 Apr 16;181(2):346-361.e17. doi: 10.1016/j.cell.2020.03.049.

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Phase separation provides a mechanism to reduce noise in cells.
Klosin A, Oltsch F, Harmon T, Honigmann A, Jülicher F, Hyman AA, Zechner C. Science. 2020 Jan 24;367(6476):464-468. doi: 10.1126/science.aav6691. PMID: 31974256

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FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy. Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J. Acta Neuropathol. 2019 Apr 1. doi:10.1007/s00401-019-01998-x.

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Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps. Jawerth LM, Ijavi M, Ruer M, Saha S, Jahnel M, Hyman AA, Jülicher F, Fischer-Friedrich E. Phys Rev Lett. 2018 Dec 21;121(25):258101. doi: 10.1103/PhysRevLett.121.258101.

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Phase separation provides a mechanism to reduce noise in cells. Florian Oltsch, Adam Klosin, Frank Julicher, Anthony A. Hyman, Christoph Zechner. bioRxiv 524231; doi: https://doi.org/10.1101/524231

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Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J. EMBO J. 2018 Dec 10. pii: e99876. doi: 10.15252/embj.201899876.

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Positioning of Particles in Active Droplets. Zwicker D, Baumgart J, Redemann S, Müller-Reichert T, Hyman AA, Jülicher F. Phys Rev Lett. 2018 Oct 12;121(15):158102. doi: 10.1103/PhysRevLett.121.158102

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Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication Compartments. Heinrich BS, Maliga Z, Stein DA, Hyman AA, Whelan SPJ. MBio. 2018 Sep 4;9(5). pii: e02290-17. doi: 10.1128/mBio.02290-17.

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A user’s guide for phase separation assays with purified proteins. Alberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA. J Mol Biol. 2018 Jun 23. pii: S0022-2836(18)30667-3. doi: 10.1016/j.jmb.2018.06.038. [Epub ahead of print]

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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins.Wang J, Choi JM, Holehouse AS, Lee HO, Zhang X, Jahnel M, Maharana S, Lemaitre R, Pozniakovsky A, Drechsel D, Poser I, Pappu RV, Alberti S, Hyman AA. Cell. 2018 Jul 26;174(3):688-699.e16. doi: 10.1016/j.cell.2018.06.006. Epub 2018 Jun 28.

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The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion. Ivanov MP, Ladurner R, Poser I, Beveridge R, Rampler E, Hudecz O, Novatchkova M, Hériché JK, Wutz G, van der Lelij P, Kreidl E, Hutchins JR, Axelsson-Ekker H, Ellenberg J, Hyman AA, Mechtler K, Peters JM. EMBO J. 2018 Jun 21. pii: e97150. doi: 10.15252/embj.201797150. [Epub ahead of print]

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Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery. Kroschwald S, Munder MC, Maharana S, Franzmann TM, Richter D, Ruer M, Hyman AA, Alberti S. Cell Rep. 2018 Jun 12;23(11):3327-3339. doi: 10.1016/j.celrep.2018.05.041.
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RNA buffers the phase separation behavior of prion-like RNA binding proteins. Maharana S, Wang J, Papadopoulos DK, Richter D, Pozniakovsky A, Poser I, Bickle M, Rizk S, Guillén-Boixet J, Franzmann T, Jahnel M, Marrone L, Chang YT, Sterneckert J, Tomancak P, Hyman AA, Alberti S. Science. 2018 Apr 12. pii: eaar7366. doi:10.1126/science.aar7366.

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Controlling compartmentalization by non-membrane-bound organelles. Wheeler RJ, Hyman AA. Philos Trans R Soc Lond B Biol Sci. 2018 May 26;373(1747). pii: 20170193. doi: 10.1098/rstb.2017.0193.

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Protein Dynamics in Complex DNA Lesions. Aleksandrov R, Dotchev A, Poser I, Krastev D, Georgiev G, Panova G, Babukov Y, Danovski G, Dyankova T, Hubatsch L, Ivanova A, Atemin A, Nedelcheva-Veleva MN, Hasse S, Sarov M, Buchholz F, Hyman AA, Grill SW, Stoynov SS. Mol Cell. 2018 Mar 15;69(6):1046-1061.e5. doi: 10.1016/j.molcel.2018.02.016.
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Tau protein liquid-liquid phase separation can initiate tau aggregation. Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. EMBO J. 2018 Feb 22. pii: e98049. doi: 10.15252/embj.201798049

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Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M. Elife. 2018 Feb 22;7. pii: e32282. doi: 10.7554/eLife.32282.

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Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A. Nat Commun. 2018 Jan 23;9(1):335. doi: 10.1038/s41467-017-02299-1.

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Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy. Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey U, Hyman AA, Sterneckert JL. Stem Cell Reports. 2018 Jan 17. pii: S2213-6711(17)30566-0. doi: 10.1016/j.stemcr.2017.12.018. [Epub ahead of print]

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Phase separation of a yeast prion protein promotes cellular fitness. Franzmann TM, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S. Science. 2018 Jan 5;359(6371). pii: eaao5654. doi: 10.1126/science.aao5654.

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Organization and Function of Non-dynamic Biomolecular Condensates. Woodruff JB, Hyman AA, Boke E. Trends Biochem Sci. 2017 Dec 16. pii: S0968-0004(17)30218-9. doi: 10.1016/j.tibs.2017.11.005. [FullText]

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Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit. Enos SJ, Dressler M, Gomes BF, Hyman AA, Woodruff JB. Biol Open. 2017 Dec 8. pii: bio.029777. doi: 10.1242/bio.029777. [FullText]

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Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.
Toyoda Y, Cattin CJ, Stewart MP, Poser I, Theis M, Kurzchalia TV, Buchholz F, Hyman AA, Müller DJ.
Nat Commun. 2017 Nov 2;8(1):1266. [FullText]

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Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase. 
Hernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA.
Cell Reports. 2017 Sep 5; 20(10):2304-2312. [FullText]

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Molecular biology: A liquid reservoir for silent chromatin.
Klosin A, Hyman AA. Nature (2017). [PDF]

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The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin.
Woodruff JB, Gomes BF, Widlund PO, Mahamid J, Honigmann A, Hyman AA.
Cell. 2017. 169(6)1066-1077. [FullText][VideoAbstract]

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Stem cells: the new “model organism.”
Drubin DG, Hyman AA.
Mol Biol Cell, 2017. 28(11)1409-1411. [FullText]

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ATP as a biological hydrotrope.
Patel A, Malinovska L, Saha S, Wang J, Alberti S, Krishnan Y, Hyman AA.
Science. 2017 May 18;356(6339):753-756.  [FullText][PDF][Video Abstract]

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An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.
Mateju D, Franzmann TM, Patel A, Kopach A, Boczeck EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S.
The EMBO Journal (2017) e201695957. [FullText]

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Biomolecular condensates: organizers of cellular biochemistry.
Banani SF, Lee HO, Hyman AA, Rosen MK.
Nat Rev Mol Cell Biol. 2017 Feb 22. [PDF][PubMed]

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Common molecular pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Jochen H. Weishaupt, Tony Hyman, Ivan Dikic.
Trends in Molecular Medicine. 2016 Sep; 22(9):769-83. [PDF][PubMed]

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Growth and division of active droplets provides a model for protocells
David Zwicker, Rabea Seyboldt, Christoph A. Weber, Anthony A. Hyman & Frank Jülicher
Nature Physics. 2016. [PDF][FullText]

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The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability.
Pécréaux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J.
Biophys J. 2016 Oct 18;111(8):1773-1784. [FullText]

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In vitro reconstitution of a membrane switch mechanism for the polarity protein LGL.
Visco I, Hoege C, Hyman AA, Schwille P.
J Mol Biol. 2016 Oct 6. pii: S0022-2836(16)30418-1. [PubMed]

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Are aberrant phase transitions a driver of cellular aging?
Alberti S, Hyman AA.
Bioessays. 2016 Oct;38(10):959-68. doi: 10.1002/bies.201600042. Epub 2016 Aug 24. [FullText]

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Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.
Saha S, Weber CA, Nousch M, Adame-Arana O, Hoege C, Hein MY, Osborne-Nishimura E, Mahamid J, Jahnel M, Jawerth L, Pozniakovski A, Eckmann CR, Jülicher F, Hyman AA.
Cell. 2016 Sep 8;166(6):1572-1584.e16. doi: 10.1016/j.cell.2016.08.006. Epub 2016 Sep 1. [PubMed][VideoAbstract]

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Polo-like kinase phosphorylation determines C. elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation.
Wueseke O, Zwicker D, Schwager A, Wong YL, Ogema K, Jülicher F, Hyman AA, Woodruff JB. Biology Open 2016 5:1431-1440. [FullText][VideoAbstract]

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Rheology of the Active Cell Cortex in Mitosis.
Fischer-Friedrich E, Toyoda Y, Cattin CJ, Müller DJ, Hyman AA, Jülicher F.
Biophys J. 2016; 111(3):589-600. [FullText]

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Amyloid-like self-assembly of a cellular compartment.
Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison T.
Cell. 2016; 166, 637-650. [PDF]

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A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher temperatures.
Leaver M, Kienle S, Begasse ML, Sommer RJ, Hyman AA.
Biol Open. 2016 Jul 18. pii: bio.018127. doi: 10.1242/bio.018127. [FullText] [Video Abstract]

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Priority of discovery in the life sciences.
Vale RD and Hyman AA.
eLife. 2016;5:e16931. [PDF]

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Visualizing the molecular sociology at the HeLa cell nuclear periphery.
Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Cuellar LK, Förster F, Hyman AA, Plitzko JM, Baumeister W.
Science. 2016 Feb; 351(6276):969-72. [PubMed]

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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M.
Cell. 2015 Oct 22;163(3):712-23. doi: 10.1016/j.cell.2015.09.053. Epub 2015 Oct 22. [FullText][PubMed]

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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S.
Cell, 27 August 2015. [FullText] [Video Abstract]

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Method: In vitro analysis of pericentriolar material assembly.
Woodruff JB, Hyman AA.
Methods Cell Biol. 2015;129:369-82. [PubMed] [PDF]

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Centrosomes. Regulated assembly of a supramolecular scaffold in vitro.
Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S,Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA.
Science. 2015 May 15;348(6236):808-12. [FullText] [PDF Reprint]

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Emergent properties of the metaphase spindle.
Reber S, Hyman AA.
Cold Spring Harb Perspect Biol. 2015 Jul 1;7(7). [PubMed] [PDF]

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Temperature dependence of cell division timing accounts for a shift in the thermal limits of C. elegans and C. briggsae.
Begasse M, Leaver M, Vazquez F, Grill SW, Hyman AA.
Cell Rep. 2015 Feb 4; 10: 647-653. [FullText]

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Liquid-liquid phase separation in biology.
Hyman AA, Weber CA, Jülicher F.
Annu Rev Cell Dev Biol. 2014 Oct 11;30:39-58. [PDF]

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Quantification of surface tension and internal pressure generated by single mitotic cells.
Fischer-Friedrich, E, Hyman AA, Jülicher F, Müller DJ, Heleniusa J.
Sci Rep. 2014; 4: 6213. [Full Text]

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The C. elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm prior to incorporation into the PCM matrix.
Wuekese O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA.
Mol Biol Cell. 2014 Aug 7. pii: mbc.E13-09-0514. [PubMed]

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Products of the Parkinson’s disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.
Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, Kurzchalia T.
Biol Open. 2014 Jul 25. pii: BIO20149399. [FullText]

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Pericentriolar material structure and dynamics.
Woodruff JB, Wueseke O, Hyman AA.
Phil. Trans. R. Soc. B. 2014 July; 369, 20130459. [PDF]

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Essays/Interviews

Essays/Interviews

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Stem cells: the new “model organism.”
Mol Biol Cell, 2017. 28(11)1409-1411. [FullText]
Drubin DG, Hyman AA.

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On Research Funding and the Power of Youth
ASCB Newsletter. 2016 Oct. [PDF]

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Hyman AA, Desai A, Walter P.

Interview with Tony Hyman

Lab Times. 2016 Apr, p39. [FullText]

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Priority of discovery in the life sciences.
eLife. 2016;5:e16931. [PDF]

Vale RD and Hyman AA.

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Encouraging Innovation.
Mol Biol Cell. 2014 Feb;25(4):427-8. [PDF]

Hyman AA.

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Funding Innovative Science.
Science. 2013 Jan. 11; Vol. 339 no. 6116 p. 119. [Article]

Hyman AA.

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In Retrospect: The Origin of Life.
Nature. 2012 [PDF]

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Hyman AA, Brangwynne CP

Some thoughts on German success.
DNN. 2012. [PDF] [online version]

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Hyman AA.

ASCB Profile
ASCB Newsletter. 2012 Nov. [PDF]

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How To Write a Paper
Tony Hyman [PDF]

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Beyond Oil and Water — Phase Transitions in Cells

Science. 2012 Aug 31; 337: 1047. [PDF]

Hyman AA, Simons K

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The new cell biology: Beyond HeLa cells

Nature. 2011 Nov 30;480(7375):34. [PDF][PubMed]

Hyman AA, Simons K

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Whither systems biology
Phil. Trans. R. Soc. B. 2011 366, 3635-3637. [PDF]

Hyman AA.

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Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm
Dev Cell. 2011 Jul 19;21(1):14-6. [PDF]

Hyman AA, Brangwynne CP

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Q & A – Tony Hyman
Curr Biol. 2011 Apr 12;21(7):R240-2. [PDF]

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Automating Cell Biology: Genomics as an Industrial Revolution
ASCB Newsletter. 2011 Mar. [PDF]

Durbin R, Hyman AA

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European vs. U.S. Careers: Your PhD as Your Passports

ASCB Newsletter. 2010 Oct. [PDF]

Hyman AA.

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Anthony Hyman: From unlikely scientist to Royal Society Fellow
J Cell Biol. 2007 Dec 31;179(7):1330-1. [PDF]

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A pipeline for Europe
Nature. 2007 Sep 13;449(7159):256. [PDF]

Hyman AA, Simons K

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Boveri revisited (EMBO Gold Medal Review 2003)

EMBO J. 2005 Mar 23;24(6):1104-10. [PDF]

Hyman AA.

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No man is an island…

Current Bio. 1996; 6(5):491. [PDF]

Hyman AA.

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Reviews


Reviews

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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing.

Alberti S, Hyman AA.Nat Rev Mol Cell Biol. 2021 Jan 28. doi: 10.1038/s41580-020-00326-6. Online ahead of print.PMID: 33510441 Review.
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Drops and fibers – how biomolecular condensates and cytoskeletal filaments influence each other.
Wiegand T, Hyman AA. Emerg Top Life Sci. 2020 Oct 13:ETLS20190174. doi: 10.1042/ETLS20190174

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Organization and Function of Non-dynamic Biomolecular Condensates. Woodruff JB, Hyman AA, Boke E. Trends Biochem Sci. 2017 Dec 16. pii: S0968-0004(17)30218-9. doi: 10.1016/j.tibs.2017.11.005. [FullText]

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Klosin A, Hyman AA.
Molecular biology: A liquid reservoir for silent chromatin.
Nature. 2017 Jun 21. [PDF]

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Banani SF, Lee HO, Hyman AA, Rosen MK.
Biomolecular condensates: organizers of cellular biochemistry.
Nat Rev Mol Cell Biol. 2017 Feb 22. [PDF]

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Alberti S, Hyman AA.
Are aberrant phase transitions a driver of cellular aging?
Bioessays. 2016 Oct;38(10):959-68. doi: 10.1002/bies.201600042. Epub 2016 Aug 24. [FullText]

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Hasse S, Hyman AA, Sarov M. TransgeneOmics – A transgenic platform for protein localization based function exploration.
Methods. 2015 Oct 17. pii: S1046-2023(15)30124-9. doi: 10.1016/j.ymeth.2015.10.005. [Epub ahead of print] Review. [PubMed]

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Reber S, Hyman AA. Emergent properties of the metaphase spindle.
Cold Spring Harb Perspect Biol. 2015 Jul 1;7(7). [PubMed] [PDF]

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Hyman AA, Weber CA, Jülicher F. Liquid-liquid phase separation in biology.
Annu Rev Cell Dev Biol. 2014 Oct 11;30:39-58. [PDF]

Woodruff JB, Wueseke O, Hyman AA. Pericentriolar material structure and dynamics. Phil. Trans. R. Soc. B. 2014 July; 369, 20130459. [PDF]

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Hoege C, Hyman AA.  Principles of PAR polarity in Caenorhabditis elegans embryos. Nat Rev Mol Cell Biol. 2013 May;14(5):315-22.  [PubMed] [PDF]

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Goehring NW, Hyman AA.  Organelle Growth Control through Limiting Pools of Cytoplasmic Components. Curr Biol. 2012 May 8;22(9):R330-9.  [PubMed]

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Reber S, Hyman AA. Samurai sword sets spindle size.
Cell. 2011 Dec 9;147(6):1224-5. [PubMed]

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Howard J, Hyman AA. Growth, fluctuation and switching at microtubule plus ends. Nat Rev Mol Cell Biol. 2009 Jun 10. [PDF]

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Cowan CR, Hyman AA.  Acto-myosin reorganization and PAR polarity in C. elegans. Development. 2007 Mar;134(6):1035-43. [PDF]

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Howard J, Hyman AA.  Microtubule polymerases and depolymerases.
Curr Opin Cell Biol. 2007 Feb;19(1):31-5. [PDF]

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Oegema K, Hyman AA. Cell division.
WormBook. 2006 Jan 19:1-40.[WormBook]

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Kinoshita K, Noetzel TL, Arnal I, Drechsel DN, Hyman AA.  Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1. J Muscle Res Cell Motil.  2006;27(2):107-14. [PDF]

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Hyman AA, Howard J. Cell structure and dynamics. 
Curr Opin Cell Biol. 2005 Feb;17(1):1-2. [PDF]

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Cowan CR, Hyman AA.   Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. Annu Rev Cell Dev Biol. 2004;20:427-53. [PDF]

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Howard J and Hyman AA. Dynamics and mechanics of the microtubule plus end. Nature. 2003; 422 (6933): 753-8. [PDF]

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Wittmann T, Hyman AA, Desai A.  The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol. 2001 E28-34.[PDF]

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Hyman AA. Centrosomes: Sic transit gloria centri
Curr Biol. 2000 Apr 6;10(7):R276-8.  [Article]

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bioRxiv CBG-CSBD

bioRxiv channel of the CBG and CSBD

http://connect.biorxiv.org/relate/content/129