Even though it’s 35°C outside and the wasp season is in full swing, a sizeable group of scientists gathered outside the entrance of the MPI-CBG to listen to Patrick McCall and Samir Vaid walk them through their research interests and outcomes in the second week of our summer chalk talk series. Patrick McCall, an ELBE […]
Recent work from Dresden (2017) suggests that centrosomes are condensates that nucleate in part by concentrating soluble tubulin. Here we show that indeed tubulin is extremely concentrated at centrosome in C. elegans embryos, suggesting that such a tubulin concentration could indeed play a key role in nucleation. References 1-https://www.ncbi.nlm.nih.gov/pubmed/28575670 2-https://www.ncbi.nlm.nih.gov/pubmed/31636117
In ALS, a mutated nuclear protein, FUS (fused in sarcoma), mislocalises to the cytoplasm and aggregates in stress granules. This leads to a liquid to solid transition of the granules and a consequent degeneration of the motor neuron (motor neuron die-back ). We show that lipoamide and lipoic acid can prevent the aggregation of FUS and consequently […]
Lee CF, Brangwynne CP, Gharakhani J, Hyman AA, Jülicher F. Spatial organization of the cell cytoplasm by position-dependent phase separation. Phys Rev Lett. 2013 Aug 23; 111(8):088101. [PubMed][PDF]
