Hyman Lab News
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FlexiBAC, our open source protein expression system
One of great things here at the MPI-CBG are our Service and Facilities, among them the protein expression facility (PEPC), which has been heavily used by us in recent years. In collaboration with Jeff Woodruff, a former postdoc, they developed FlexiBAC, an amazingly versatile protein expression system in insect cells, which was developed with a huge range of different constructs and tags, which might fit your needs as well.
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We held the first EMBO phase separation course here at the MPI-CBG
The course was organized together with the Tang and Alberti lab, including morning lectures, theoretical or experimental parts during the day and a relaxing evening part. Importantly, we included as well the project ideas of our participants.
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Phase separation buffers noise in cells
In collaboration with the Zechner and Jülicher groups, we now show in theory and experiments that liquid-liquid phase separation (LLPS) can be a very effective mechanism to buffer protein concentrations against gene expression noise.
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Rheology of protein condensates using optical traps
Louise and her coworkers now developed a novel method based on optical traps to study the frequency-dependent rheology and the surface tension of P-granule protein PGL-3 condensates as a function of salt concentration.
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How do you choose a research topic?
Choosing a research topic is an important decision at any level. The choice shapes decisions about what graduate lab to join, which post-doctoral position to pursue, how to start an independent lab, and what companies might make good employers.
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Phase Transitions form Virus Replication Compartments in Cells
Former postdoc Zoltan worked with the Whelan lab on VSV (Vesicular Stomatitis Virus). They show liquid-liquid phase separation (LLPS) seems to play an important role in host-pathogen interactions.