Hyman Lab News
Tony wins Carl Zeiss lecture award
The award to Tony comes from the German Society for Cell Biology for excellent achievements in research and was established in 1990 by the company Zeiss. Tony will lecture on September 27th in Tübingen during the fall conference of the German Society for Biochemistry and Molecular Biology (GBM)
Small molecules that dissolve stress granules
In ALS, a mutated nuclear protein, FUS (fused in sarcoma), mislocalises to the cytoplasm and aggregates in stress granules. This leads to a liquid to solid transition of the granules and a consequent degeneration of the motor neuron (motor neuron die-back.)
Suzanne Eaton
We, past and current members of the Hyman lab, are reeling from the sudden and tragic loss of Suzanne Eaton. She was a wonderful person who lives on in our hearts. In this difficult time, we stand together with her family and colleagues.
FlexiBAC, our open source protein expression system
One of great things here at the MPI-CBG are our Service and Facilities, among them the protein expression facility (PEPC), which has been heavily used by us in recent years. In collaboration with Jeff Woodruff, a former postdoc, they developed FlexiBAC, an amazingly versatile protein expression system in insect cells, which was developed with a huge range of different constructs and tags, which might fit your needs as well.
We held the first EMBO phase separation course here at the MPI-CBG
The course was organized together with the Tang and Alberti lab, including morning lectures, theoretical or experimental parts during the day and a relaxing evening part. Importantly, we included as well the project ideas of our participants.
Phase separation buffers noise in cells
In collaboration with the Zechner and Jülicher groups, we now show in theory and experiments that liquid-liquid phase separation (LLPS) can be a very effective mechanism to buffer protein concentrations against gene expression noise.