2026

• Origins of the Intrinsic Redox Activity of Biomolecular Condensates.

  research article

  Yu W, Zhou Y, Yang L, Yan X, Smukowski SN, Ma Y, Fan J, Goo YA, Hyman AA, Dai Y. Origins of the Intrinsic Redox Activity of Biomolecular Condensates. J Am Chem Soc. 2026 Apr 8;148(13):14443-14452.

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• In vitro binding energies capture Klf4 occupancy across the human genome

  bioRxiv

  Schwager A, Neipel J, Savich Y, Diehl D, Jülicher F, Hyman AA, Grill SW. arXiv preprint arXiv:2601.16151. 2026 Jan 22.

  Read In vitro binding energies capture Klf4 occupancy across the human genome

• CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host-pathogen interactions.

  research article

  Kuznetsova K, Scheremetjew M, Yin J, Moon H, Vargas DA, Hadarovich A, Lewis N, Hoege C, Chow CFW, Kuster D, Nijssen J, Hernandez-Armendariz A, Savage JC, Wei Y, Zedlitz S, Singh HR, Ghosh S, Kemraj AP, Hersemann L, Hyman AA, Mitrea DM, Toth-Petroczy A. Nucleic Acids Res. 2026 Jan 6;54(D1):D375-D382.

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2025

• Fast, Bright, and Reversible Fluorescent Labeling of Rhodamine-Binding Proteins

  research article

  Kompa J, Dornfeld LJ, Porzberg N, Jang S, Zedlitz S, Lilje SH, Catapano C, Jocher D, Merk L, Hoege C, Mao R, Wilhelm J, Dietz MS, Tarnawski M, Hiblot J, Hyman AA, Heilemann M, Johnsson K. 2026 Jan 14;148(1):1419-1429.

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• CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host–pathogen interactions

  research article

  Kuznetsova K, Scheremetjew M, Yin J, Moon H, Vargas DA, Hadarovich A, Lewis L, Hoege C, Chow CFW, Kuster D, Nijssen J, Hernandez-Armendariz A, Savage JC, Wei Y, Zedlitz S, Singh HR, Ghosh S, Kemraj AP, Hersemann L, Hyman AA, Mitrea DM, Toth-Petroczy A. Nucleic Acids Research. 2025.

  Read CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host–pathogen interactions

• Structural insights into mitotic-centrosome assembly

  bioRxiv

  Mohamad N, Wong S, Majumdar A, Wainman A, Holland-Kaye I, Hubatsch L, Novak Z, Pozniakovsky Z, Ruer-Gruss M, Haensele AFM, Caballe AA, Johnson A, Lea AM, Hyman AA, Raff JW. bioRxiv 2025.

  Read Structural insights into mitotic-centrosome assembly

• A label-free method for measuring the composition of multicomponent biomolecular condensates

  research article

  McCall, PM, Kim, K, Shevchenko, A, Ruer-Gruß, M, Peychl, J, Guck, J, Shevchenko, A, Hyman, AA, Brugués J. Nat. Chem. 2025

  Read A label-free method for measuring the composition of multicomponent biomolecular condensates

• Quantifying collective interactions in biomolecular phase separation

  research article

  Ausserwöger H, de Csilléry E, Qian D, Krainer G, Welsh TJ, Sneideris T, Franzmann TM, Qamar S, Erkamp NA, Nixon-Abell J, Kar M, St George-Hyslop P, Hyman AA, Alberti S, Pappu RV, Knowles TPJ. Quantifying collective interactions in biomolecular phase separation. Nat Commun. 2025 Aug 19;16(1):7724.

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• SARS-CoV-2 nucleocapsid protein directly prevents cGAS-DNA recognition through competitive binding

  research article

  Gutmann T, Kuster D, Hyman AA. Proc Natl Acad Sci U S A. 2025 Jul;122(26):e2426204122. doi: 10.1073/pnas.2426204122. Epub 2025 Jun 23. PMID: 40549905.

  Read SARS-CoV-2 nucleocapsid protein directly prevents cGAS-DNA recognition through competitive binding

• A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro

  research article

  Lewis NS, Zedlitz S, Ausserwöger H, McCall PM, Hubatsch L, Nousch M, Ruer-Gruß M, Hoege C, Jülicher F, Eckmann CR, Knowles TPJ, Hyman AA. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2412218122

  Read A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro

• Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

  research article

  Yan X, Kuster D, Mohanty P, Nijssen J, Pombo-García K, Garcia Morato J, Rizuan A, Franzmann TM, Sergeeva A, Ly AM, Liu F, Passos PM, George L, Wang SH, Shenoy J, Danielson HL, Ozguney B, Honigmann A, Ayala YM, Fawzi NL, Dickson DW, Rossoll W, Mittal J, Alberti S, Hyman AA. Cell. 2025 May 15:S0092-8674(25)00509-4. doi: 10.1016/j.cell.2025.04.039. Epub ahead of print. PMID: 40412392.

  Read Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

• Small-molecule dissolution of stress granules by redox modulation benefits ALS models

  research article

  Uechi H, Sridharan S, Nijssen J, Bilstein J, Iglesias-Artola JM, Kishigami S, Casablancas-Antras V, Poser I, Martinez EJ, Boczek E, Wagner M, Tomschke N, de Jesus Domingues AM, Pal A, Doeleman T, Kour S, Anderson EN, Stein F, Lee HO, Zhang X, Fritsch AW, Jahnel M, Fürsch J, Murthy AC, Alberti S, Bickle M, Fawzi NL, Nadler A, David DC, Pandey UB, Hermann A, Stengel F, Davis BG, Baldwin AJ, Savitski MM, Hyman AA, Wheeler RJ. Nat Chem Biol. 2025 May 14.

  Read Small-molecule dissolution of stress granules by redox modulation benefits ALS models

• Functional specificity in biomolecular condensates revealed by genetic complementation

  review

  Sabari BR, Hyman AA, HniszD. Nature Reviews Genetics. 2025 April; 26, 279–290 (2025)

  Read Functional specificity in biomolecular condensates revealed by genetic complementation

• Single-step discovery of high-affinity RNA ligands by UltraSelex

  research article

  Zhang Y, Jiang Y, Kuster D, Ye Q, Huang W, Fürbacher S, Zhang J, Doll P, Lin W, Dong S, Wang H, Tang Z, Ibberson D, Wild K, Sinning I, Hyman AA, Jäschke A. Nat Chem Biol. 2025 Mar 31. doi: 10.1038/s41589-025-01868-6

  Read Single-step discovery of high-affinity RNA ligands by UltraSelex

• SUMO2/3 conjugation of TDP-43 protects against aggregation

  research article

  Verde EM, Antoniani F, Mediani L, Secco V, Crotti S, Ferrara MC, Vinet J, Sergeeva A, Yan X, Hoege C, Stuani C, Paron F, Kao TT, Shrivastava R, Polanowska J, Bailly A, Rosa A, Aronica E, Goswami A, Shneider N, Hyman AA, Buratti E, Xirodimas D, Franzmann TM, Alberti S, Carra S. Sci Adv. 2025 Feb 21;11(8):eadq2475.

  Read SUMO2/3 conjugation of TDP-43 protects against aggregation

• Mesoscale landscaping of the TRIM protein family reveals a novel human condensatopathy

  bioRxiv

  Singh HR, Sharma V, Nijssen J, Pozniakovski A, Rubin A, Liang L, Ball D, Hong S, Gauntner V, Yu G, Ranga A, Salant D, Hildebrandt F, Hyman AA , Majmundar AJ. bioRxiv. 2025 Jan 2:2025.01.02.630836

  Read Mesoscale landscaping of the TRIM protein family reveals a novel human condensatopathy

2024

• Assembly of tight junction belts by ZO1 surface condensation and local actin polymerization

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  research article

  Sun D, Zhao X, Wiegand T, Martin-Lemaitre C, Borianne T, Kleinschmidt L, Grill SW, Hyman AA, Weber C, Honigmann A. Developmental Cell. 2024 Dec 31

  Read Assembly of tight junction belts by ZO1 surface condensation and local actin polymerization

• Transport kinetics across interfaces between coexisting liquid phases

  bioRxiv

  open access

  Hubatsch L, Bo S, Harmon TS, Hyman AA, Weber CA, Julicher F. bioRxiv. 2024 Dec 20; 2024.12.20.629798v2

  Read Transport kinetics across interfaces between coexisting liquid phases

• PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms

  open access

  research article

  Hadarovich A, Singh HR, Ghosh S, Scheremetjew M, Rostam N, Hyman AA, Toth-Petroczy A. Nat Commun. 2024 Dec 11; 15:10668.

  Read PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms

• Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayers

  open access

  research article

  Wiegand T, Liu J, Vogeley L, Geisler J, Fritsch AW, Hyman AA, Grill SW. Proceedings of the National Academy of Science. 2024 Dec 4;s121(50).

  Read Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayers

• Functional specificity in biomolecular condensates revealed by genetic complementation

  review

  Sabari BR, Hyman AA, Hnisz D. Nat Rev Genet. 2024 Oct 21.

  Read Functional specificity in biomolecular condensates revealed by genetic complementation

• Solutes unmask differences in clustering versus phase separation of FET proteins

  research article

  Mrityunjoy Kar, Laura T Vogel, Gaurav Chauhan, Suren Felekyan, Hannes Ausserwöger, Timothy J Welsh, Furqan Dar, Anjana R Kamath, Tuomas PJ Knowles, Anthony A Hyman, Claus AM Seidel, Rohit V Pappu

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• Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

  bioRxiv

  open access

  research article

  Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M. Franzmann, Aleksandra Sergeeva, Patricia M. Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L. Danielson, Alf Honigmann, Yuna M. Ayala, Nicolas L. Fawzi, Jeetain Mittal, Simon Alberti, Anthony A. Hyman. bioRxiv 2024.01.23.576837

  Read Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

• Local and dynamic regulation of neuronal glycolysis in vivo

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  Wolfe AD, Koberstein JN, Smith CB, Stewart ML, Gonzalez IJ, Hammarlund M, Hyman AA, Stork PJS, Goodman RH, Colón-Ramos DA. Proc. Natl. Acad. Sci. 2024 Jan 10; 121(3):e2314699121.

  Read Local and dynamic regulation of neuronal glycolysis in vivo

2023

• CD-CODE: crowdsourcing condensate database and encyclopedia

  open access

  research article

  Rostam N, Ghosh S, Chow CF, Hadarovich A, Landerer C, Ghosh R, Moon H, Hersemann L, Mitrea DM, Klein IA, Hyman AA. Nature Methods. 2023 May;20(5):673-6.

  Read CD-CODE: crowdsourcing condensate database and encyclopedia

• Molecular mechanisms of stress-induced reactivation in mumps virus condensates

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  research article

  Zhang X, Sridharan S, Zagoriy I, Eugster Oegema C, Ching C, Pflaesterer T, Fung HKH, Becher I, Poser I, Müller CW, Hyman AA, Savitski MM, Mahamid J.Cell. 2023 Apr 27;186(9):1877-1894.e27.

  Read Molecular mechanisms of stress-induced reactivation in mumps virus condensates

2022

• SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

  open access

  research article

  Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA.Mol Cell. 2022 Oct 6;82(19):3712-3728.e10.

  Read SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

• Adaptation to environmental temperature in divergent clades of the nematode Pristionchus pacificus

  open access

  research article

  Leaver M, Moreno E, Kayhan M, McGaughran A, Rödelsperger C, Sommer RJ, Hyman AA. Evolution. 2022 Aug 1;76(8):1660-73.

  Read Adaptation to environmental temperature in divergent clades of the nematode Pristionchus pacificus

• Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions

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  research article

  Kar M, Dar F, Welsh TJ, Vogel LT, Kühnemuth R, Majumdar A, Krainer G, Franzmann TM, Alberti S, Seidel CA, Knowles TP. Proceedings of the National Academy of Sciences. 2022 Jul 12;119(28):e2202222119.

  Read Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions

• Sequence-dependent surface condensation of a pioneer transcription factor on DNA

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  research article

  Morin JA, Wittmann S, Choubey S, Klosin A, Golfier S, Hyman AA, Jülicher F, Grill SW. Nature Physics. 2022 Mar;18(3):271-6.

  Read Sequence-dependent surface condensation of a pioneer transcription factor on DNA

• Molecular mechanism of stress-induced reactivation in mumps virus condensates

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  research article

  Zhang X, Sridharan S, Zagoriy I, Oegema CE, Ching C, Pflaesterer T, Fung HK, Poser I, Müller CW, Hyman AA, Savitski MM. Biophysical Journal. 2022 Feb 11;121(3):148a.

  Read Molecular mechanism of stress-induced reactivation in mumps virus condensates

2021

• Glycine-rich peptides from FUS have an intrinsic ability to self-assemble into fibers and networked fibrils

  open access

  research article

  Kar M, Posey AE, Dar F, Hyman AA, Pappu RV. Biochemistry. 2021 Oct 14;60(43):3213-22.

  Read Glycine-rich peptides from FUS have an intrinsic ability to self-assemble into fibers and networked fibrils

• Quantitative theory for the diffusive dynamics of liquid condensates

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  research article

  Hubatsch L, Jawerth LM, Love C, Bauermann J, Tang TD, Bo S, Hyman AA, Weber CA. Elife. 2021 Oct 12;10:e68620.

  Read Quantitative theory for the diffusive dynamics of liquid condensates

• Local thermodynamics govern formation and dissolution of Caenorhabditis elegans P granule condensates

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  research article

  Fritsch AW, Diaz-Delgadillo AF, Adame-Arana O, Hoege C, Mittasch M, Kreysing M, Leaver M, Hyman AA, Jülicher F, Weber CA. Proceedings of the National Academy of Sciences. 2021 Sep 14;118(37):e2102772118.

  Read Local thermodynamics govern formation and dissolution of Caenorhabditis elegans P granule condensates

• HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

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  research article

  Boczek EE, Fürsch J, Niedermeier ML, Jawerth L, Jahnel M, Ruer-Gruß M, Kammer KM, Heid P, Mediani L, Wang J, Yan X. Elife. 2021 Sep 6;10:e69377.

  Read HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

• Phosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo

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  research article

  Jang S, Xuan Z, Lagoy RC, Jawerth LM, Gonzalez IJ, Singh M, Prashad S, Kim HS, Patel A, Albrecht DR, Hyman AA. Biophysical journal. 2021 Apr 6;120(7):1170-86.

  Read Phosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo

• Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

  review

  Alberti S, Hyman AA. Nature reviews Molecular cell biology. 2021 Mar;22(3):196-213.

  Read Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

• Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

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  Krainer G, Welsh TJ, Joseph JA, St George-Hyslop P, Hyman AA, Collepardo-Guevara R, Alberti S, Knowles TP. Biophysical Journal. 2021 Feb 12;120(3):28a.

  Read Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

• ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes

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  Rondelet A, Pozniakovsky A, Namboodiri D, Da Silva RC, Singh D, Leuschner M, Poser I, Ssykor A, Berlitz J, Schmidt N, Röhder L. Life science alliance. 2021 Feb 1;4(2).

  Read ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes

2020

• ASCB Keith Porter Lecture

  essay

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  Hyman AA. Molecular biology of the cell. 2020 Dec 15;31(26):2864-7.

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• Drops and fibers—how biomolecular condensates and cytoskeletal filaments influence each other

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  review

  Wiegand T, Hyman AA. Emerging topics in life sciences. 2020 Dec 12;4(3):247.

  Read Drops and fibers—how biomolecular condensates and cytoskeletal filaments influence each other

• Protein condensates as aging Maxwell fluids

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  Jawerth L, Fischer-Friedrich E, Saha S, Wang J, Franzmann T, Zhang X, Sachweh J, Ruer M, Ijavi M, Saha S, Mahamid J. Science. 2020 Dec 11;370(6522):1317-23.

  Read Protein condensates as aging Maxwell fluids

• Erratum: Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps [Phys. Rev. Lett. 121, 258101 (2018)]

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  Jawerth LM, Ijavi M, Ruer M, Saha S, Jahnel M, Hyman AA, Jülicher F, Fischer-Friedrich E. Physical Review Letters. 2020 Nov 23;125(22):229901.

  Read Erratum: Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps [Phys. Rev. Lett. 121, 258101 (2018)]

• Generalized models for bond percolation transitions of associative polymers

  research article

  Choi JM, Hyman AA, Pappu RV. Physical Review E. 2020 Oct 6;102(4):042403.

  Read Generalized models for bond percolation transitions of associative polymers

• Partitioning of cancer therapeutics in nuclear condensates

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  Klein IA, Boija A, Afeyan LK, Hawken SW, Fan M, Dall'Agnese A, Oksuz O, Henninger JE, Shrinivas K, Sabari BR, Sagi I. Science. 2020 Jun 19;368(6497):1386-92.

  Read Partitioning of cancer therapeutics in nuclear condensates

• Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

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  Iserman C, Altamirano CD, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D. Cell. 2020 May 14;181(4):818-31.

  Read Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

• RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation

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  research article

  Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IR, Wang J, Mateju D, Poser I. Cell. 2020 Apr 16;181(2):346-61.

  Read RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation

• Phase separation provides a mechanism to reduce noise in cells

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  Klosin A, Oltsch F, Harmon T, Honigmann A, Jülicher F, Hyman AA, Zechner C. Science. 2020 Jan 24;367(6476):464-8.

  Read Phase separation provides a mechanism to reduce noise in cells

2019

• Soluble tubulin is significantly enriched at mitotic centrosomes

  open access

  research article

  Baumgart J, Kirchner M, Redemann S, Bond A, Woodruff J, Verbavatz JM, Jülicher F, Müller-Reichert T, Hyman AA, Brugués J. Journal of Cell Biology. 2019 Dec 2;218(12):3977-85.

  Read Soluble tubulin is significantly enriched at mitotic centrosomes

• Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

  open access

  research article

  Siahaan V, Krattenmacher J, Hyman AA, Diez S, Hernández-Vega A, Lansky Z, Braun M. Nature cell biology. 2019 Sep;21(9):1086-92.

  Read Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

• FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

  open access

  research article

  Marrone L, Drexler HC, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R. Acta neuropathologica. 2019 Jul 1;138:67-84.

  Read FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

• Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

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  research article

  Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M. The EMBO journal. 2019 Jan 15;38(2):e99876.

  Read Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

• Publisher Correction: Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

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  Stewart MP, Helenius J, Toyoda Y, Ramanathan SP, Muller DJ, Hyman AA. Nature. 2019;571(7764):E5-.

  Read Publisher Correction: Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

2018

• Salt-dependent rheology and surface tension of protein condensates using optical traps

  research article

  Jawerth LM, Ijavi M, Ruer M, Saha S, Jahnel M, Hyman AA, Jülicher F, Fischer-Friedrich E. Physical review letters. 2018 Dec 18;121(25):258101.

  Read Salt-dependent rheology and surface tension of protein condensates using optical traps

• Phase transitions drive the formation of vesicular stomatitis virus replication compartments

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  research article

  Heinrich BS, Maliga Z, Stein DA, Hyman AA, Whelan SP. MBio. 2018 Nov 7;9(5):10-128.

  Read Phase transitions drive the formation of vesicular stomatitis virus replication compartments

• A user's guide for phase separation assays with purified proteins

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  Alberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA. Journal of molecular biology. 2018 Nov 2;430(23):4806-20.

  Read A user's guide for phase separation assays with purified proteins

• Positioning of Particles in Active Droplets

  research article

  Zwicker D, Baumgart J, Redemann S, Müller-Reichert T, Hyman AA, Jülicher F. Physical review letters. 2018 Oct 12;121(15):158102.

  Read Positioning of Particles in Active Droplets

• The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion

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  research article

  Ivanov MP, Ladurner R, Poser I, Beveridge R, Rampler E, Hudecz O, Novatchkova M, Hériché JK, Wutz G, van Der Lelij P, Kreidl E. The EMBO journal. 2018 Aug 1;37(15):e97150.

  Read The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion

• A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins

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  Wang J, Choi JM, Holehouse AS, Lee HO, Zhang X, Jahnel M, Maharana S, Lemaitre R, Pozniakovsky A, Drechsel D, Poser I. Cell. 2018 Jul 26;174(3):688-99.

  Read A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins

• Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery

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  Kroschwald S, Munder MC, Maharana S, Franzmann TM, Richter D, Ruer M, Hyman AA, Alberti S. Cell reports. 2018 Jun 12;23(11):3327-39.

  Read Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery

• Controlling compartmentalization by non-membrane-bound organelles

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  review

  Wheeler RJ, Hyman AA. Philosophical Transactions of the Royal Society B: Biological Sciences. 2018 May 26;373(1747):20170193.

  Read Controlling compartmentalization by non-membrane-bound organelles

• RNA buffers the phase separation behavior of prion-like RNA binding proteins

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  Maharana S, Wang J, Papadopoulos DK, Richter D, Pozniakovsky A, Poser I, Bickle M, Rizk S, Guillén-Boixet J, Franzmann TM, Jahnel M. Science. 2018 May 25;360(6391):918-21.

  Read RNA buffers the phase separation behavior of prion-like RNA binding proteins

• Tau protein liquid-liquid phase separation can initiate tau aggregation

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  Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C. The EMBO journal. 2018 Apr 3;37(7):e98049.

  Read Tau protein liquid-liquid phase separation can initiate tau aggregation

• Protein dynamics in complex DNA lesions

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  Aleksandrov R, Dotchev A, Poser I, Krastev D, Georgiev G, Panova G, Babukov Y, Danovski G, Dyankova T, Hubatsch L, Ivanova A. Molecular cell. 2018 Mar 15;69(6):1046-61.

  Read Protein dynamics in complex DNA lesions

• Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria

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  research article

  Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M. Elife. 2018 Feb 22;7:e32282.

  Read Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria

• Isogenic FUS-eGFP iPSC reporter lines enable quantification of FUS stress granule pathology that is rescued by drugs inducing autophagy

  open access

  research article

  Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey U, Hyman AA, Sterneckert JL. Stem cell reports. 2018 Feb 13;10(2):375-89.

  Read Isogenic FUS-eGFP iPSC reporter lines enable quantification of FUS stress granule pathology that is rescued by drugs inducing autophagy

• Organization and function of non-dynamic biomolecular condensates

  review

  Woodruff JB, Hyman AA, Boke E. Trends in biochemical sciences. 2018 Feb 1;43(2):81-94.

  Read Organization and function of non-dynamic biomolecular condensates

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• Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

  open access

  research article

  Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A. Nature communications. 2018 Jan 23;9(1):335.

  Read Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

• Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit

  open access

  research article

  Enos SJ, Dressler M, Gomes BF, Hyman AA, Woodruff JB. Biology Open. 2018 Jan 15;7(1):bio029777.

  Read Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit

• Phase separation of a yeast prion protein promotes cellular fitness

  open access

  research article

  Franzmann TM, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA. Science. 2018 Jan 5;359(6371):eaao5654.

  Read Phase separation of a yeast prion protein promotes cellular fitness

2017

• Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding

  open access

  research article

  Toyoda Y, Cattin CJ, Stewart MP, Poser I, Theis M, Kurzchalia TV, Buchholz F, Hyman AA, Müller DJ. Nature communications. 2017 Nov 2;8(1):1266.

  Read Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding

• Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase

  open access

  research article

  Hernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA. Cell reports. 2017 Sep 5;20(10):2304-12.

  Read Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase

• Molecular biology: A liquid reservoir for silent chromatin

  commentary

  open access

  review

  Klosin A, Hyman AA. Nature. 2017 Jul 13;547(7662):168-9.

  Read Molecular biology: A liquid reservoir for silent chromatin

• An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

  open access

  research article

  review

  Mateju D, Franzmann TM, Patel A, Kopach A, Boczek EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S. The EMBO journal. 2017 Jun 14;36(12):1669-87.

  Read An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

• The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin

  open access

  research article

  Woodruff JB, Gomes BF, Widlund PO, Mahamid J, Honigmann A, Hyman AA. Cell. 2017 Jun 1;169(6):1066-77.

  Read The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin

• Stem cells: the new "model organism"

  open access

  perspective

  Drubin DG, Hyman AA. Molecular biology of the cell. 2017 Jun 1;28(11):1409-11.

  Read Stem cells: the new "model organism"

• ATP as a biological hydrotrope

  research article

  Patel A, Malinovska L, Saha S, Wang J, Alberti S, Krishnan Y, Hyman AA. Science. 2017 May 19;356(6339):753-6.

  Read ATP as a biological hydrotrope

  PDF

• Biomolecular condensates: organizers of cellular biochemistry

  review

  Banani SF, Lee HO, Hyman AA, Rosen MK. Nature reviews Molecular cell biology. 2017 May;18(5):285-98.

  Read Biomolecular condensates: organizers of cellular biochemistry

  PDF

• Growth and division of active droplets provides a model for protocells

  open access

  research article

  Zwicker D, Seyboldt R, Weber CA, Hyman AA, Jülicher F. Nature Physics. 2017 Apr;13(4):408-13.

  Read Growth and division of active droplets provides a model for protocells

2016

• In vitro reconstitution of a membrane switch mechanism for the polarity protein LGL

  research article

  Visco I, Hoege C, Hyman AA, Schwille P. Journal of Molecular Biology. 2016 Dec 4;428(24):4828-42.

  Read In vitro reconstitution of a membrane switch mechanism for the polarity protein LGL

  PDF

• The mitotic spindle in the one-cell C. elegans embryo is positioned with high precision and stability

  open access

  research article

  Pecreaux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J. Biophysical Journal. 2016 Oct 18;111(8):1773-84.

  Read The mitotic spindle in the one-cell C. elegans embryo is positioned with high precision and stability

• Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation

  open access

  research article

  Wueseke O, Zwicker D, Schwager A, Wong YL, Oegema K, Jülicher F, Hyman AA, Woodruff JB. Biology open. 2016 Oct 15;5(10):1431-40.

  Read Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation

• Are aberrant phase transitions a driver of cellular aging?

  open access

  perspective

  Alberti S, Hyman AA. BioEssays. 2016 Oct;38(10):959-68.

  Read Are aberrant phase transitions a driver of cellular aging?

• Polar positioning of phase-separated liquid compartments in cells regulated by an mRNA competition mechanism

  open access

  research article

  Saha S, Weber CA, Nousch M, Adame-Arana O, Hoege C, Hein MY, Osborne-Nishimura E, Mahamid J, Jahnel M, Jawerth L, Pozniakovski A. Cell. 2016 Sep 8;166(6):1572-84.

  Read Polar positioning of phase-separated liquid compartments in cells regulated by an mRNA competition mechanism

• Common molecular pathways in amyotrophic lateral sclerosis and frontotemporal dementia

  review

  Weishaupt JH, Hyman T, Dikic I. Trends in molecular medicine. 2016 Sep 1;22(9):769-83.

  Read Common molecular pathways in amyotrophic lateral sclerosis and frontotemporal dementia

  PDF

• A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher temperatures

  open access

  research article

  Leaver M, Kienle S, Begasse ML, Sommer RJ, Hyman AA. Biology Open. 2016 Aug 15;5(8):1111-7.

  Read A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher temperatures

• Rheology of the active cell cortex in mitosis

  open access

  research article

  Fischer-Friedrich E, Toyoda Y, Cattin CJ, Müller DJ, Hyman AA, Jülicher F. Biophysical journal. 2016 Aug 9;111(3):589-600.

  Read Rheology of the active cell cortex in mitosis

• Amyloid-like self-assembly of a cellular compartment

  open access

  research article

  Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ. Cell. 2016 Jul 28;166(3):637-50.

  Read Amyloid-like self-assembly of a cellular compartment

• Priority of discovery in the life sciences

  open access

  opinion

  Vale RD, Hyman AA. Elife. 2016 Jun 16;5:e16931.

  Read Priority of discovery in the life sciences

• TransgeneOmics - a transgenic platform for protein localization based function exploration

  open access

  review

  Hasse S, Hyman AA, Sarov M. Methods. 2016 Mar 1;96:69-74.

  Read TransgeneOmics - a transgenic platform for protein localization based function exploration

• Visualizing the molecular sociology at the HeLa cell nuclear periphery

  research article

  Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Kuhn Cuellar L, Förster F, Hyman AA, Plitzko JM, Baumeister W. Science. 2016 Feb 26;351(6276):969-72.

  Read Visualizing the molecular sociology at the HeLa cell nuclear periphery

  PDF

2015

• A human interactome in three quantitative dimensions organized by stoichiometries and abundances

  open access

  research article

  Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA. Cell. 2015 Oct 22;163(3):712-23.

  Read A human interactome in three quantitative dimensions organized by stoichiometries and abundances

• A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation

  open access

  research article

  Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A. Cell. 2015 Aug 27;162(5):1066-77.

  Read A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation

• Emergent properties of the metaphase spindle

  open access

  review

  Reber S, Hyman AA. Cold Spring Harbor perspectives in biology. 2015 Jul 1;7(7):a015784.

  Read Emergent properties of the metaphase spindle

• Regulated assembly of a supramolecular centrosome scaffold in vitro

  open access

  research article

  Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A. Science. 2015 May 15;348(6236):808-12.

  Read Regulated assembly of a supramolecular centrosome scaffold in vitro

• Temperature dependence of cell division timing accounts for a shift in the thermal limits of C. elegans and C. briggsae

  open access

  research article

  Begasse ML, Leaver M, Vazquez F, Grill SW, Hyman AA. Cell reports. 2015 Feb 10;10(5):647-53.

  Read Temperature dependence of cell division timing accounts for a shift in the thermal limits of C. elegans and C. briggsae

• Method: In vitro analysis of pericentriolar material assembly

  research article

  Woodruff JB, Hyman AA. Methods in cell biology. 2015 Jan 1 (Vol. 129, pp. 369-382). Academic Press.

  Read Method: In vitro analysis of pericentriolar material assembly

  PDF

2014

• The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix

  open access

  research article

  Wueseke O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA. Molecular Biology of the Cell. 2014 Oct 10;25(19):2984.

  Read The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix

• Liquid-liquid phase separation in biology

  open access

  review

  Hyman AA, Weber CA, Jülicher F. Annual review of cell and developmental biology. 2014 Oct 6;30:39-58.

  Read Liquid-liquid phase separation in biology

• Pericentriolar material structure and dynamics

  open access

  review

  Woodruff JB, Wueseke O, Hyman AA. Philosophical Transactions of the Royal Society B: Biological Sciences. 2014 Sep 5;369(1650):20130459.

  Read Pericentriolar material structure and dynamics

• Quantification of surface tension and internal pressure generated by single mitotic cells

  open access

  research article

  Fischer-Friedrich E, Hyman AA, Jülicher F, Müller DJ, Helenius J. Scientific reports. 2014 Aug 29;4(1):6213.

  Read Quantification of surface tension and internal pressure generated by single mitotic cells

• Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

  open access

  research article

  Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, Kurzchalia TV. Biology open. 2014 Jul 25;3(8):777-84.

  Read Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

• Encouraging innovation

  open access

  opinion

  Mol Biol Cell. 2014 Feb;25(4):427-8.

  Read Encouraging innovation

2013

• Principles of PAR polarity in Caenorhabditis elegans embryos

  opinion

  review

  Hoege C, Hyman AA. Nature reviews Molecular cell biology. 2013 May;14(5):315-22.

  Read Principles of PAR polarity in Caenorhabditis elegans embryos

  PDF

• Funding innovative science

  open access

  opinion

  Hyman AA. Science. 2013 Jan 11;339(6116):119-.

  Read Funding innovative science

2012

• In retrospect: the origin of life

  essay

  open access

  Hyman AA, Brangwynne C. Nature. 2012 Nov;491, 524-525

  Read In retrospect: the origin of life

• Beyond oil and water — phase transitions in cells

  open access

  perspective

  Hyman AA, Simons K. Science. 2012 Aug 31;337(6098):1047-9.

  Read Beyond oil and water — phase transitions in cells

• Organelle growth control through limiting pools of cytoplasmic components

  open access

  review

  Goehring NW, Hyman AA. Current Biology. 2012 May 8;22(9):R330-9.

  Read Organelle growth control through limiting pools of cytoplasmic components

2011

• Whither systems biology

  open access

  opinion

  Hyman AA. Philosophical Transactions of the Royal Society B: Biological Sciences. 2011 Dec 27;366(1584):3635-7.

  Read Whither systems biology

• Samurai sword sets spindle size

  open access

  review

  Reber S, Hyman AA. Cell. 2011 Dec 9;147(6):1224-5.

  Read Samurai sword sets spindle size

• Beyond HeLa cells

  commentary

  open access

  Hyman AH, Simons K. Nature. 2011 Dec 1;480(7375):34-.

  Read Beyond HeLa cells

• Beyond stereospecificity: liquids and mesoscale organization of cytoplasm

  open access

  Hyman AA, Brangwynne CP. Developmental cell. 2011 Jul 19;21(1):14-6.

  Read Beyond stereospecificity: liquids and mesoscale organization of cytoplasm

• Q&A: Tony Hyman

  interview

  open access

  Hyman T. Tony Hyman. Current Biology. 2011 Apr 12;21(7):R240-2.

  Read Q&A: Tony Hyman

2009

• Growth, fluctuation and switching at microtubule plus ends

  opinion

  review

  Howard J, Hyman AA. Nature Reviews Molecular Cell Biology. 2009 Aug;10(8):569-74.

  Read Growth, fluctuation and switching at microtubule plus ends

  PDF

2007

• Anthony Hyman: From unlikely scientist to Royal Society Fellow

  interview

  open access

  Williams R. The Journal of Cell Biology. 2007 Dec 12;179(7):1330.

  Read Anthony Hyman: From unlikely scientist to Royal Society Fellow

• A pipeline for Europe

  open access

  opinion

  Hyman T, Simons K. Nature. 2007 Sep 13;449(7159):256-.

  Read A pipeline for Europe

• Acto-myosin reorganization and PAR polarity in C. elegans

  review

  Cowan CR, Hyman AA. Development 15 March 2007; 134 (6): 1035-1043.

  Read Acto-myosin reorganization and PAR polarity in C. elegans

  PDF

• Microtubule polymerases and depolymerases

  review

  Howard J, Hyman AA. Current opinion in cell biology. 2007 Feb 1;19(1):31-5.

  Read Microtubule polymerases and depolymerases

  PDF

2006

• Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1

  review

  Kinoshita K, Noetzel TL, Arnal I, Drechsel DN, Hyman AA. Journal of Muscle Research & Cell Motility. 2006 Feb;27:107-14.

  Read Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1

  PDF

2005

• Boveri revisited

  essay

  open access

  Hyman AA. The EMBO Journal. 2005 Mar 23;24(6):1104-10.

  Read Boveri revisited

• Cell structure and dynamics

  review

  Hyman AA, Howard J. Current Opinion in Cell Biology. 2005 Feb 1;17(1):1-2.

  Read Cell structure and dynamics

  PDF

2004

• Asymmetric cell division in C. elegans: cortical polarity and spindle positioning

  review

  Cowan CR, Hyman AA. Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. Annu. Rev. Cell Dev. Biol.. 2004 Nov 10;20(1):427-53.

  Read Asymmetric cell division in C. elegans: cortical polarity and spindle positioning

  PDF

2003

• Dynamics and mechanics of the microtubule plus end

  review

  Howard J, Hyman AA. Nature. 2003 Apr 17;422(6933):753-8.

  Read Dynamics and mechanics of the microtubule plus end

  PDF

2001

• The spindle: a dynamic assembly of microtubules and motors

  review

  Wittmann T, Hyman A, Desai A. Nature cell biology. 2001 Jan;3(1):E28-34.

  Read

2000

• Centrosomes: Sic transit gloria centri

  open access

  review

  Hyman AA. Current Biology. 2000 Apr 1;10(7):R276-8.

  Read Centrosomes: Sic transit gloria centri

1996

• No man is an island…

  open access

  Hyman T. Current Biology. 1996 May 1;6(5):491.

  Read No man is an island…