Hyman Lab News
Check out our new user’s guide for phase separation assays with purified proteins!
The formation of membrane-less organelles and compartments by protein phase separation is an important way in which cells organize their cytoplasm and nucleoplasm. In vitro phase separation assays with purified proteins have become the standard way to investigate proteins that form membrane-less compartments.
Buffering disease: How the nucleus keeps proteins in check
Many age-related diseases affect the nervous system. One prominent example of a neurodegenerative disease is Amyotrophic Lateral Sclerosis (ALS). The brain tissue of ALS patients typically shows aggregates of so-called prion-like RNA-binding proteins.
Richard's review on controlling non-membrane-bound organelles is out
The review discusses energetically favourable interactions that could drive condensation, and on the basis of that, make qualitative predictions about how cells may control compartmentalization by condensates.
Edgar is giving a talk at the CSHL meeting Protein Homeostasis in Health and Disease
The Cold Spring Harbor meeting on Protein Homeostasis is taking place from April 17th-21th and Edgar will speak about how Molecular chaperones control the physical state of membrane-less compartments.
Congratulations to Stephanie for her successful collaboration with the Zerial lab!
By investigating mitochondrial-endosomal contact sites we made the surprising observation that the small GTPase Rab5 translocates from early endosomes to mitochondria upon oxidative stress.
Congratulations to Sina and Adam for their fellowships!
Sina and Adam received both each an EMBO postdoc fellowship as well as a Marie Curie postdoc fellowship. This is a great success for both of them but as well for the lab. And yes, of course we celebrated it…