The 2015 paper “A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation” (Avinash Patel) has been recognized by Cell as one of the most impactful studies of the past decade! It’s featured in Cell Line: 2014–2024, a special collection highlighting the journal’s most influential publications over its 50-year history.
This groundbreaking work explores how the ALS-associated protein FUS shifts from a liquid-like state to a more solid form, especially when affected by disease mutations. These findings have played a key role in advancing our understanding of ALS and other neurodegenerative diseases.
The paper has been cited over 2,500 times and is listed alongside some of the biggest scientific breakthroughs of the decade, including Nobel-winning research—a truly impressive achievement.
So proud to be part of the lab behind this work, and huge congratulations to everyone who contributed!
You can explore the full Cell Line: 2014–2024 feature on Cell’s website here.