Our latest publication is out now in Cell! In this work, led by Jeff Woodruff, we used defined components to reconstitute a minimal centrosome in vitro that can nucleate microtubule asters. Our results suggest that the centrosome acts a selective phase that nucleates microtubules by concentrating microtubule polymerases and soluble tubulin.
Read the full paper in Cell, and watch the video abstract below!
The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin.
Jeffrey B. Woodruff, Beatriz Ferreira Gomes, Per O. Widlund, Julia Mahamid, Alf Honigmann, Anthony A. Hyman.
Cell, 2017. 169(6)1066-1077.