Category Archives: Video

Our latest publication, in collaboration with Yamuna Krishnan in Chicago, is out today in Science! In this work, we show that ATP can act as a biological hydrotrope, keeping proteins soluble. Hydrotropes are amphiphilic small molecules that solubilize hydrophobic molecules in aqueous solutions. While ATP is most commonly known as the energy source for cells, there […]

In new work published this month in Biology Open, Oliver Wueseke, David Zwicker, Jeff Woodruff, and colleagues show that PKL-1 phosphorylation of the centrosome scaffold protein SPD-5 is a key regulatory step which determines centrosome size and density. Importantly, they show that this step is not necessary for proper maintenance or function of the centrosome. […]

In a collaboration with the group of Frank Jülicher at the MPI-PKS, Shamba Saha and colleagues have discovered that an RNA-competition mechanism is at the heart of correct P granule positioning in C. elegans. P granules are liquid-like compartments that segregate to the posterior end of the one-cell embryo before cell division. Previous work in […]

Congratulations to Mark Leaver on his publication in Biology Open, which is open access and available now online! Click here for the full text. And watch Mark’s 2 minute video abstract below! Leaver M, Kienle S, Begasse ML, Sommer RJ, Hyman AA. A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher […]

Congratulations to Avinash, Kate, and colleagues for their recent publication in Cell! This work, a close collaboration between our lab and Simon Alberti’s lab, focuses on a protein called FUS, which is implicated in ALS (also known as Lou Gehrig’s disease). By using in vitro and in vivo studies, they show that FUS normally forms liquid compartments. However, when these compartments are “aged” in vitro, they […]