Highlights Membrane-less organelles form by phase separation Membrane-less organelles can be reconstituted from minimal components Phase-separating proteins are difficult to purify and handle We provide guidelines and protocols for working with phase-separating proteins The formation of membrane-less organelles and compartments by protein phase separation is an important way in which cells organize their cytoplasm and […]
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Load More...Ever wonder how cellular condensates contribute to function? Can condensates deliver robust functional output in spite of changing conditions- short-term effects of chemical modifications, intrinsic mutational changes, accumulation of high local concentration of sticky molecules? https://twitter.com/biorxivpreprint/status/1526359522058682369
Composition can buffer protein dynamics within liquid-like condensates. https://biorxiv.org/cgi/content/short/2022.05.16.492059v1 #bioRxiv
