Phase Separation – Working hypothesis

The core hypothesis under investigation is that manipulating key condensate scaffolds hinders disease-driving processes without interfering with the enzymology required for physiological cell functions.


The strategy followed to tackle this hypothesis entails:

  1. Performing biophysical characterization of condensate scaffolds and their separation properties
  2. Establishing and manipulating the molecular grammar of scaffold formation
  3. Testing the role of identified condensate scaffolds in disease progression


The main output of this research would be to detect and control disease relevant biomolecular condensates.


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