Tony wins the 19th annual prize together with Clifford Brangwynne of Princeton university and Michael Rosen of the Southwestern University in Texas for their work on defining phase-separated biomolecular condensates. In a statement of the Wiley foundation their work was recognized for… “revealing a new principle for subcellular compartmentalization based on formation of phase-separated biomolecular […]
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Pre-percolation clusters might have functional relevance especially as active entities when compared to condensates that may primarily be for sequestration. Key is that coexisting dilute phases & sub-saturated solutions are not featureless. Forces us to see the "whole" picture. https://twitter.com/PappulabWashU/status/1544597919650570240
@MrityunjoyK's paper is the most important work I've been part of & shaped. Consistent with phase separation coupled to percolation (PSCP≠LLPS) FET proteins form pre-percolation form clusters below cSat & clusters condense above cSat. 🎉Joy & @FarquadDar
https://www.pnas.org/doi/full/10.1073/pnas.2202222119
