Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M. Elife. 2018 Feb 22;7. pii: e32282. doi: 10.7554/eLife.32282 Mitochondrial stress response is essential for cell survival, and damaged mitochondria are a hallmark of neurodegenerative diseases. Thus, it is fundamental to understand how mitochondria […]
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Load More...Ever wonder how cellular condensates contribute to function? Can condensates deliver robust functional output in spite of changing conditions- short-term effects of chemical modifications, intrinsic mutational changes, accumulation of high local concentration of sticky molecules? https://twitter.com/biorxivpreprint/status/1526359522058682369
Composition can buffer protein dynamics within liquid-like condensates. https://biorxiv.org/cgi/content/short/2022.05.16.492059v1 #bioRxiv
