New publication on Sas-4

Members of the Hyman lab (Ina, Andrei, and Tony) are contributing authors on the latest paper from Jay Gopalakrishnan’s group, “Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis.” Sas-4 is a conserved centrosomal protein that was discovered and initially characterized in the Hyman lab (Kirkham et al, Cell 2003). Our Cell paper revealed that Sas-4 is required for centriole duplication, and that the amount of Sas-4 at centrioles dictates centrosome size. This new paper provides “insights into how Sas-4 proteins tether PCM complexes for the assembly of functional centrosomes.”